Exploring Genetic Factors in Autophagy Regulation: Individual Variations and Strategies for Reducing Disease Risk

Speaker: Dr. Penny Kendall-Reed, ND

Date: Wednesday, April 9, 2025

Time: 8:00 PM – 9:30 PM EDT

Autophagy has gained significant attention in medical research in recent years, not only for its role in anti-aging but also for its potential influence on conditions  in preventing diseases such as cancer, Alzheimer’s, inflammatory bowel disease (IBD), and diabetes. ^1,2 Autophagy is the natural process in which cells eliminate and recycle damaged cellular components. When inefficient, damaged materials accumulate in cells, impairing cell function and contributing to the ability to catalyze disease processes. to the development of diseases, such as cancer, Alzheimer’s disease, inflammatory bowel disease (IBD) and diabetes.

However, the rates of autophagy vary among individuals, affecting their risk of disease and aging. Traditional fasting diets can help some people enter autophagy within 2 to 3 days, while others may require 5 days or more, along with a more rigorous regimen and additional supplementation. ³ How can health practitioners distinguish between these individuals? The answer lies in genetics. Genes influence the production of proteins like Beclin1, SIRT6, and ATG16L1, which stimulate autophagy. ⁴ Stress and inflammation also impact these pathways.

Come explore the latest research in autophagy and how to effectively integrate it into practice.

Learning Objectives: 

1. Understand Types of Autophagy: Learn about the 3 main types and their cellular mechanisms.

2. Recognize Impact on Health: Explore autophagy’s role in aging processes and various diseases.

3. Examine Rates: Understand autophagy rates can vary among individuals and the associated risks for diseases, such as cancer and diabetes.

4. Identify Associated SNPs: Discuss SNPs involved in autophagy and learn how to address them with diet, natural supplementation, and exercise.

5. Compare Case Studies: Review and compare case studies using SNP analysis and rates of autophagy to personalize protocol recommendations.

Click here to register.

References:

¹ Li YY, Qin ZH, Sheng R. The Multiple Roles of Autophagy in Neural Function and Diseases. Neurosci Bull. 2024;40(3):363-382. doi:10.1007/s12264-023-01120-y

² White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer. 2012;12(6):401-410. Published 2012 Apr 26. doi:10.1038/nrc3262

³ Basavarajaiah DM, Narasimhamurhy B (2020) Predictive Modeling of Autophagy Interrelation with Fasting. J Biostat Biometric App 5(1): 102

⁴ Iachettini S, Trisciuoglio D, Rotili D, et al. Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells. Cell Death Dis. 2018;9(10):996. Published 2018 Sep 24. doi:10.1038/s41419-018-1065-0

Contact details

Name: Nestlé Health Science

Phone: -

Email: educationnhsc@ca.nestle.com

Date And Time

Wed, Apr 09th, 2025

8:00 pm - 9:30 pm